Hua
3,3'- diindolylmethane
Whakaahuatanga
Ko te 3,3'-diindolylmethane he takawaenga rongoa;Ka kitea i roto i nga phytochemicals maori no Cruciferae Plants, waikawa catalyzed hua tauhohenga, indole-3-methanol;Kei a ia te mahi o te kaihoko anti-tumor;I raro i te ahua o te kukū āhua tiketike, e kore e taea e te pärönaki te whakatere tika i te apoptosis o nga pūtau mate pukupuku tangata, engari sensitize ara ki te whakaawe i te apoptosis o ngā pūtau mate pukupuku tangata;Ko te Chemicalbookdim he whakakorikori i te mowhiti G1 i roto i te mate pukupuku uma o te tangata MCF-7 na roto i te tikanga me te whakahuatanga whakauru;Ko Dim he aukati kaha o te mitochondrial h+-atpase;Hei kaiwhakatairanga tipu tipu hou, kua whakamahia te pouri me ona hua ki roto i te rangahau punaha pai-taiao.
Nga korero hua
Nama nama:1968-05-4
Ma: ≥98%
Tātai:C17H14N2
Tātai Wt.：246.31
Ingoa matū:3,3'-Diindolylmethane
Kupu taurite : :3,3'-Diindolylmethane(DIM);Di(1H-indol-3-yl);Tahu:Indole;3,3'-DIINDOLYLMETHANE,>=98%(HPLC);3,3'-METHYLENEBIS- 1H-INDOLE;3,3'-METHYLENEBISINDOLE;3,3'-METHYLENEDIINDOLE;3,3'-DIINDOLYLMETANA
Ira Whakarewa:167 °C
Ira Kohua:230 °C
Wairewa: Chloroform (He iti), Methanol (He iti)
Te ahua: Te paura ma
Te tuku me te rokiroki
Rokiroki pūmautanga Te pāmahana rokiroki e taunaki ana -20°C.
Te Whakaritenga Whakanohoia te indole (1.17 g, 10 mmol), CTAB (50% mol) me te waikawa oxalic (50% mol) ki roto i te 25 ml te ipu porotaka-raro kaki kotahi, ka tapirihia te 5 ml wai whakakorehia, ka whakaoho kia 5 meneti katahi ka tāpirihia te wairewa formaldehyde wai (0.38 g wairewa, 5 mmol formaldehyde) maturuturu.Tauhohenga mo te 3 haora i te pāmahana rūma ka mutu te tauhohenga.I tangohia te otinga tauhohenga me te 15 ml o te ethyl acetate i roto i nga wahanga e toru, ka kohia te wahanga waro ka whakamaroke ki te Na2SO4 anhydrous mo te 5 haora.I tangohia te whakarewa i raro i te pehanga iti me te whakamarokehia mai i te ranunga o te methanol me te wai (methanol/H2ChemicalbookO = 10/1) kia puta he totoka ma 3,3'-diindolylmethane i roto i te 85% hua.Ko te Bioactivity3,3'-Diindolylmethane (DIM) te hua nakunaku matua o te indole-3-carbinol, he matū anticancer pea i roto i nga huawhenua cruciferous.3,3'-Diindolylmethane (DIM) he kaitawhai kaha parakore o te androgenreceptor (AR) .
Kua whakaatuhia e nga rangahau in vitro ko DIM he radioprotector whai hua me te whakaiti, e mahi ana ma te whakaihiihi i nga urupare DDR-rite ki te ATM me te tohu ora NF-κB. Ka taea e DIM te aukati i te whakaekenga o nga pūtau pukupuku, te angiogenesis, te whakanui me te whakaawe i te apoptosis ma te whakarereke i nga huarahi tohu. penei i te AKT, NF-κB me FOXO3.Ka taea hoki te aukati i te whakaputanga o te ira ira na te estrogen me te whakapouri i te ahotea reticulum endoplasmic.Ka taea e chemicalbookDIM te whakarereke i te paopaotanga o te estrogen me te whakahē i nga mahi kaiawhina o te estrogen me te androgen.I roto i nga rangahau vivo kua whakaatuhia he whai hua te DIM ki te rauropi punaha i muri i nga whakahaere maha.I roto i nga whakamatautau in vivo, i whakaratohia e DIM te whakamarumaru iraruke, te whakaheke ranei.I roto i nga kopa noa, ka whakahohehia e DIM te ATM.Ka taea te whakahaere i te dIM ki nga kiore ma te whakakii-waha (250 mg/kg) me te nui o te koiora me te kore t whakapeka.
