Hua
Waikawa Polyinosinic-Polycytidylic Acid
Tātai Hanganga
Tinana
Te ahua: te paura ma, te ma ranei
Kiato.
Te rewa.
Kohuatanga.
Te whakakoi
Ira hiko.
Raraunga Haumaru
Kāwai mōrearea.
Tau Kawenga Taonga Morearea.
Te kāwai takai.
Taupānga
Ko te Poly I:C e mohiotia ana ki te taunekeneke ki te kaitoi-rite ki te kaiwhiwhi 3 (TLR3), e whakaatuhia ana i te membrane endosomal o B-cell, macrophages me nga pūtau dendritic.He rite te hanganga o te Poly I:C ki te RNA paerua-rua, kei roto i etahi wheori, he mea whakaihiihi "maori" o TLR3.No reira, ko te Poly I:C ka taea te whakaaro he tairitenga waihanga o te RNA paerua-rua, he taputapu noa mo te rangahau pūtaiao mo te punaha mate.
Te ahuatanga
Ko tenei hua he whakakorikori interferon waihanga, he polyribonucleotide taurua i tito mai i te waikawa polyinosinic me te waikawa polycytidylic.I te mea ko te interferon he momo-motuhake, he uaua ki te whakarite i nga rahinga nui mo te tono haumanu, no reira ka whakamahia te nuinga hei kaiwhakaoho interferon ki te whakauru i te interferon.I tua atu, ko te waikawa polyinosinic tonu te mahi o te awhina aukati, ka taea te whakaihiihi i te punaha reticuloendothelial, te whakarei ake i te mahi phagocytic o te phagocytes, te whakarei ake i te hanga o nga antibodies, te whakaongaonga i te tauhohenga allograft me te whakaroa i te tauhohenga mate mate.Kei a ia nga paanga antiviral me te antitumor whanui.
Nga whakamahinga me nga tikanga whakahiato
Tirohanga
Ko te waikawa Polycytidylic, e mohiotia ana ko te waikawa polyinosinic, te nucleotide polyhypoxanthine me te nucleotide polycytidine, ko tetahi o nga polynucleotides, kei roto he mekameka polynucleotide-rua o te waikawa polyinosinic me te waikawa polycytidylic, me te whakahekenga o te tae me te tohu whakarewa, me te pumau i te -20 ℃ .
Nga hua rongoa
1. He pai te whakatairanga o te waikawa Polyinosinic i runga i te mate motuhake me te kore-motuhake o te tinana.
(1) Ko nga polymyocytes e whakanui ana i nga mahi o nga pūtau mate
(2) Ko nga polymyocytes e whakatairanga ana i te whakaputanga o nga momo cytokines
(3) Te whakaurunga o te pūmua Mx e te polymyocytes
(4) Ko nga polymyocytes e whakatairanga ana i te hanga o nga antibodies i roto i te vivo
2. Te painga anti-viral o polymyocytes
Ko nga whakamatautau in vitro, nga whakamatautau kararehe me nga whakamatautau haumanu tangata kua whakamatauhia he maha nga paanga o te polymyxins, tae atu ki te huaketo kirikaa kowhai, te huaketo encephalomyelitis, te mate kirika Rift Valley, te rewharewha avian, te mate hepatitis, te mate AIDS, te waewae-me-waha. huaketo mate, wheori conjunctivitis, huaketo rash ngawari, huaketo Mengo, huaketo pox, huaketo myocarditis, huaketo Aleutian, virus coxsackie, me etahi atu. Kua whakamatauhia he pai ake te painga o te aukati o Polymyxa i te hua whakaora o te mate huaketo.
Taupānga
1.He homopolymer paerua ka taea te whakamahi hei tauira RNA ki te ako i nga tohu tohu i te taumata o TLR3 e mohio ana ki te RNA taurua-rua, koinei hoki te kaikorero matua o te urupare aukati ki nga pathogens viral.
2.Paired with polyinosinic acid to form polyinosinic cell, used for the treatment of viral hepatitis, herpes zoster, herpes simplex keratitis, herpes stomatitis, epidemic hemorrhagic fever, etc.
3. He awenga awhina aukati, he whakaihiihi i te punaha reticuloendothelial, he whakarei ake i te phagocytosis, he whakarei ake i te hanga antibody, he whakaihiihi i te hohenga allograft me te whakaroa i te tauhohenga mate mate.Kei a ia te paanga antiviral whanui me te paanga antitumor.Te nuinga whakamahia haumanu mo: ārai maimoatanga ranei o mate viral, maimoatanga o herpes zoster, keratitis herpetic, kakā viral.Te maimoatanga awhina o nga pukupuku.Ko te nuinga o nga tauhohenga kino ko te hypothermia puhoi me nga keehi takitahi o te kirika teitei i runga ake i te 38 ℃, i te nuinga o te waa ka memeha noa i roto i nga ra 1-2.Ki te kore e heke te kirika i roto i nga ra e 2, me whakamutu tonu te rongoa.Ka kitea ano te ngoikore, te waha maroke, te whanoke, te nausea, aha atu.
