Hua
Bucladesine
Tātai Hanganga
Āhuatanga ā-tinana
Te ahua: Hua mawhero ma
Te ahua rokiroki: -20°C
Wairewa H2O: 50 mg/mL
Raraunga Haumaru
No nga taonga noa
Taupānga
Ko te Dibutyryl cyclic adenosine monophosphate konutai he hua o te adenosine monophosphate cyclic, e whakamahia ana ki te hamani i te wiri cardiogenic me te ngoikore o te ngakau.I te tau 1999, i whakawhanakehia te hinu hinu adenosine monophosphate konutai Dibutyryl cyclic adenosine monophosphate hei rongoa i te mate kiri me te whewhe kiri.
Te faaineineraa o te konutai dibutyryl cyclophosphate adenosine: I roto i te ipu kei roto cyclophosphate adenosine āta tāpiri wairewa konutai waihā (3 mol/L) dropwise, te tukanga whakahaere pāmahana, dropwise mutu whakamahana ki te pāmahana rūma, te whakarite i te pH ki te 7 ~ 8 ki te otinga HCl ( 20%), tāpiri waiwaro anhydrous precipitation o ma totoka, filtration, whakamaroke ki te whiwhi i te tote konutai totoka ma;te tote konutai me te n-butyl anhydride i raro i te maru o te whakamahana N2 ki te 140 ℃ tauhohenga.Ko te aro turuki i te TLC, ka oti te tauhohenga ka heke ki te pāmahana rūma, āta tāpirihia te methyl tert-butyl ether, te tukanga o te whakakorikori kaha, Chemicalbook ki te whiwhi hua masivesivá tata ma.Ko te ranunga o te methyl tert-butyl ether me te acetone i whakatarewahia kia whiwhi ai i tetahi hua whainga paura ma.Ko te ngohe koioraDibutyryl-cAMP(Bucladesine,dbcAMP) he kaiwhakahohe PKA-permeable e mahi ana ma te peehi i te cAMP endogenous.Ko te Dibutyryl-cAMP(Bucladesine) he aukati phosphodiesterase(PDE).
Nga rangahau in vitro: Ko te Dibutyryl-cAMP te aukati i te tangohanga o te hukahuka neuronal ma te whakahohe PKA.I roto i nga hepatocytes kiore, ka whakakorehia e te Dibutyryl-cAMP te whakaaturanga synthase nitric oxide me te mahi here NF-kappaB.Ko te dibutyrChemicalbookyl-cAMP ka aukati ano hoki i te apoptosis o nga pūtau toka a TNFalpha ma te aukati i te whakatikatika FADD.
I roto i nga rangahau vivo: I roto i te tauira kiore, Bucladesine (600nM/kiore, ip) whakataka konutea pūhaumāota me te acetate mata i arai i te ngoikoretanga pupuri mahara.
